Scientific Publication

Longitudinal Brain Atrophy Rates in Presymptomatic Carriers of Genetic Frontotemporal Dementia


Jackie M. Poos, Leonie D. M. Grandpierre, Emma L. van der Ende, Jessica L. Panman, Janne M. Papma, Harro Seelaar, Esther van den Berg, Ronald van 't Klooster, Esther Bron, Rebecca Steketee, Meike W. Vernooij, Yolande A. L. Pijnenburg, Serge A. R. B. Rombouts, John van Swieten, Lize C. Jiskoot

October 26, 2022

  • This study investigated longitudinal brain atrophy rates in the presymtomatic stage of genetic frontotemporal dementia (FTD) using Quantib® ND.
  • Between different gene groups, affected brain regions and the age at which atrophy rates start to accelerate diverge from the normal aging slopes, highlighting the value of normative volumetric software for disease tracking and staging in genetic FTD.